Neurology

The MMI Advantage

Experience and Expertise

MMI’s team of scientists are experienced in both preclinical and clinical neuroimaging research, with over 75 years of collective experience in the field. We work with some of the leading global device and biopharmaceutical companies pursuing various treatments in the brain and are uniquely positioned to support your clinical trial needs.

Modality Expertise

CT

CTA

CT Perfusion

DSA

3D Angiography

MRI

DW-MRI

MRA

MR Perfusion

MMI is experienced in a wide-array of neurological studies, including acute ischemic stroke, brain aneurysms, brain neoplasms, traumatic brain injury, electro-magnetic detection of brain pathologies, and embolic protection studies. We have evaluated a wide variety of treatments and devices, including matrix-, stent- and balloon-assisted coiling of aneurysms, neurovascular thrombectomy devices, embolic protection devices, virus therapies for malignant brain tumors, neuronal physiology and metabolite variation studies, tractography and white-matter studies, functional MRI (fMRI), and advanced quantitative brain volume/atrophy analysis.

Our technical staff includes Masters- and PhD-level managers with experience in intra-cranial imaging and neurology trials. Our experts are recognized leaders in neurology, vascular imaging, and medicine. They include presidents of major professional societies, editors of leading journals, division chiefs of surgery, department chairs of radiology, national scientific award winners, and expert advisors to the FDA.

WHAT WE OFFER

Analysis Capabilities

Brain morphology (e.g. volume, lesion burden, atrophy)

Relaxometry studies (e.g. T1p mapping, T2 mapping)

Micro-infarct quantification

Lesion characterization (e.g. RANO, location, area)

Ablation quantification

Recanalization and reperfusion (e.g. ASPECTS, mTICI)

Aneurysm evaluation (e.g. neck width, occlusion, recanalization)

Trauma (e.g. ICH, CSF Leaks, cerebral contusion)

3D angiography illustrating pre- and post- treatment of a wide-neck aneurysm with coiling and stenting

DWI and ADC map capturing micro-infarcts in the brain following a TAVR procedure

Neuroangiography

Identification of infarct locations

DSA images showing pre- and post-treatment of an aneurysm with a flow diverter

Some of Our Experts

Willem Jan van Rooij, MD PhD

Interventional Neuroradiologist, Algemeen Ziekenhuis Turnhout

Dr. van Rooij specializes in imaging of aneurysms and stroke, and has published extensively on these topics, with an impressive resume of over 230 peer-reviewed publications. He currently serves on the editorial board of multiple scientific journals, including AJNR, Interventional Neuroradiology, The Open Neurosurgery Journal, and World Journal of Radiology. Dr. van Rooij obtained his MD and PhD at the University of Utrecht, Netherlands, and currently practices as an Interventional Radiologist at Algemeen Ziekenhuis Turnhout.

Reade A. De Leacy, MD, BSc, MBBS

Asst. Professor, Neurosurgery, Mount Sinai

Dr. De Leacy is the Director of the Neurointerventional Spine Program and Assistant Professor of Neurosurgery and Radiology in the Cerebrovascular Center at The Mount Sinai Hospital. Additionally, he serves as Director of Cerebrovascular Services at Mount Sinai Queens. Dr. De Leacy has published multiple peer-reviewed journal articles and book chapters in diagnostic neuroradiology, interventional radiology, and neuroendovascular surgery. Dr. De Leacy specializes in the endovascular treatment of cerebrovascular disorders including acute stroke, carotid stenosis, brain aneurysms, arteriovenous malformations, and minimally invasive spinal surgeries including biopsy, kyphoplasty, and ablative therapy for spinal and paraspinal tumors.

Relevant Scientific Resources

Neuro Webinar

Role of Imaging in Acute Ischemic Stroke

MMI’s neurovascular expert discusses the imaging modalities and endpoints relevant for the evaluation of AIS.

Closing the gap between engineers and surgeons leads to improved device design.

Neuro News

Neurosurgeon showcases implementation of novel device on live video stream

Dr. Steven Falowski broke new ground by livestreaming the implantation of neurostimulators to Medtronic engineers.

Small lesions can increase patients' risk of stroke mortality.

Neuro Publication

Small cerebral lesions associated with increased risk of stroke

A new study finds that small brain lesions previously thought to be insignificant are associated with heightened risk of stroke, increasing the importance of utilizing the very best medical imaging technology and experienced readers.

Key Publications Involving MMI

Akella NS, Twieg DB, Mikkelsen T, et al. Assessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: quality and analysis results of a phase I trial. J Magn Reson Imaging. 2004;20(6):913-22.

Bluestein KT, Pitt D, Knopp MV, et al. T1 and proton density at 7T in patients with multiple sclerosis: an initial study. J Magn Reson Imaging. 2012;30(1):19-25.

Latib A, Mangieri A, Vezzulli P, et al. First-in-Man Study Evaluating the Emblok Embolic Protection System During Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. 2020;13(7):860-868.

Liachenko S, Ramu J. Quantification and reproducibility assessment of the regional brain T2 relaxation in naïve rats at 7T. J Magn Reson Imaging. 2017;45(3):700-709

Ramu J, Konak T, Paule MG, et al. Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure. Neurotoxicology. 2016;56:225-232.

Let MMI provide insights into your clinical study imaging.

Have questions? We’ll connect you immediately to one of our scientific managers and imaging experts. Your time is precious, and we want to make the most out of it.