Quantitative Imaging Solutions for Orthopedic Clinical Trials

MMI is an experienced imaging core laboratory for orthopedic clinical trials. Since 2000, we have supported more than 150 orthopedic device and biopharmaceutical companies internationally, including 14 of the top 15 global market leaders. We have evaluated scores of unique treatments, including novel implants, drugs, and biologics, for disorders for the hip, knee, ankle, wrist, shoulder, peripheral joints, and long bones involving OA, trauma, and sports medicine. We have also evaluated multiple surgical robotic systems and AI-based diagnostics for musculoskeletal disease.

Experience and Expertise

We specialize in quantitative image analysis using validated, computer-assisted methods. Our image analysis techniques include cartilage thickness mapping, MR relaxation mapping, joint space analysis, bone density analysis, and assessment of tissue morphometry. We are also experienced with virtually all of the major semi-quantitative scoring systems to assess disease severity and response to therapy from medical imaging.

Our treatment expertise includes:

  • Orthobiologics, including Cell, Protein, and Gene Therapies
  • Tissue Scaffolds and Synthetic Implants for Cartilage Repair
  • Allografts, Chondrocyte Transplantation, and Marrow Stimulation
  • Disease-Modifying Agents, including DMOADs and DMARDs
  • Viscosupplements and Inflammatory Pain Therapies
  • Joint Fusion, Replacement, and Resurfacing (large and small joint)
  • Ligament, Tendon, and Meniscal Repair / Replacement
  • Fracture Fixation, Bone Void Fillers, and Anti-Infection Aids
  • Robotic-assisted Surgical Techniques

Faculty Directors

We offer unique clinical expertise, awareness of the latest advances in imaging, and knowledge of current regulatory trends in orthopedic device and drug trials. Our core group of orthopedic experts is led by Drs. Timothy Mosher and Mark Schweitzer.

Timothy Mosher, MD

  • Chair of Radiology, Penn State Hershey Medical Center
  • Fellowship-trained in clinical MRI at Johns Hopkins University
  • 20 years’ clinical experience in orthopedic imaging and research
  • Recognized expert in quantitative MRI of articular cartilage
  • Over 85 articles, books and book chapters on MSK imaging
  • Deputy Editor, Magnetic Imaging in Medicine; Associate Editor, Radiology; Associated Editor, Osteoarthritis and Cartilage
  • Member of the OARSI-FDA working group on structural change in OA

Mark Schweitzer, MD

  • Chair of Radiology, Stony Brook University School of Medicine
  • Fellowship-trained in Osteoradiology at UC San Diego
  • Editor-in-Chief, JMRI; Deputy Editor, Radiology
  • Former Presiding Officer of the Radiological Society of North America
  • Over 25 years’ experience in research, clinical practice, and teaching
  • 350+ published articles, 67 book chapters, and three books
  • Reviewer for more than two dozen scholarly journals
  • Served on numerous expert advisory panels, including FDA and NIH

Please browse our services or contact us to learn more.