Leading Core Lab for Spine Trials

MMI has provided imaging core lab services for FDA-regulated studies of the spine since 2000. Images from 80% of regulated spine trials are managed through our facility. Our radiologists are experienced with all forms of fusion, arthroplasty, and disc repair. Our patented Quantitative Motion Analysis software (QMA®) has the highest accuracy and reproducibility of any published method for spine image analysis. Additionally, our scientific experts have contributed hundreds of publications to the scientific literature on spine imaging and research. No other core lab offers our unique combination of experienced readers, scientific expertise, and specialized technology for spine clinical trials. (Note: QMA® is designed for investigational use only and is not for use in clinical diagnosis or patient management.)

Experience and Expertise

We have extensive experience with motion preserving technology, including total disc replacement, disc augmentation, and dynamic stabilization. Our spine fusion experience includes assessments of allografts, autografts, and bone graft substitutes. We are leaders in the evaluation of biologic products for bone and soft-tissue repair and have evaluated an array of novel treatments to slow or reverse disc degeneration and promote bone healing following spine fusion procedures.

A summary of our treatment experience is provided below.


  • Decompression
  • Fusion (Interbody, PLF, etc.)
  • Total Disc Replacement
  • Disc Repair and Regeneration
  • Facet Replacement
  • Dynamic Stabilization
  • Interspinous Distraction
  • Fracture Stabilization and Healing
  • Deformity Correction

Pathologies & Indications

  • Spinal Stenosis
  • Degenerative Disc Disease
  • Facet Degeneration
  • Instability
  • Annular Compromise
  • Compression Fracture
  • Osteoporosis
  • Scoliosis
  • Trauma

Faculty Directors

We offer unique clinical expertise, awareness of the latest advances in spine imaging, and an understanding of current regulatory requirements and trends. Our Faculty Directors for spine trials include:

John Hipp, PhD

  • Over 25 years’ experience in quantitative imaging methods for spine research
  • Recipient of the prestigious AAOS Kappa Delta Orthopedic Research Award
  • Former Director of the Spine Research Lab at Baylor College of Medicine
  • Published over 100 imaging-related papers and book chapters
  • Managed development of more than 75 spine-related imaging charters
  • Reviewer for eight leading journals including Spine and The Spine Journal

Alan Williams, MD

  • Fellowship-trained neuroradiologist with over 30 years’ clinical experience, including 17 years as a Neuroradiology Section Chief
  • Former President of the American Society of Spine Radiology
  • Published over 90 peer-reviewed papers and 10 book chapters
  • Invited speaker at many national and international meetings
  • Serves in editorial capacity at the American Journal of Neuroradiology and Radiology

Please browse our services or contact us to learn more.