Ear, Nose, & Throat
The MMI Advantage
State-of-the-art volumetric analysis capability
Through collaborations with industry experts and key opinion leaders, MMI has developed validated, custom methodologies to precisely quantify the mucosal thickening or inflammatory disease associated with Chronic Rhinosinusitis (CRS).
Experienced with multiple CRS trials
We are a preferred imaging core lab for CRS trials and have the ability to objectively characterize sinus opacification to detect minute changes that can be missed using traditional qualitative grading systems. Furthmore, MMI has supported trials involving wound healing and nasal polyp characterization.
Excellent industry
reputation
“We are blessed to have a partnership with such a great leader in CT assessment within the ENT community. The novelty and the quality of work done by Medical Metrics is unprecedented, which is instrumental for us to generate a high impact publication and awareness from ENT physicians.” - Clinical Research Manager from Top 5 Medical Device Companies
Experience and Expertise
MMI is a leading core lab for ENT trials and has developed an objective measure for characterizing sinus opacification as an imaging endpoint.
Modality Expertise
CT
MRI
Endoscopy
MMI has worked with leading pharmaceutical and device companies in the ENT space to study treatment effects in a broad subject population that includes CRS, CRS + polyposis, FESS, and ethmoidectomy. Our experience includes evaluation of drug-eluting stents, irrigation cannulas administered through the lacrimal duct, drug exhalation systems, and numerous biologics.
We have authored a variety of radiographic protocols, guidance materials, and justification documents to validate the methodologies used to quantify mucosal thickening, including the use of volumetric analysis in regulated clinical trials. MMI also has the ability to provide quick-turn analysis in support of subject eligibility screening and has experience conducting analyses in thousands of subjects in support of regulated clinical trials.
WHAT WE OFFER
Analysis Capabilities
CRS (e.g. Lund-Mackay, Zinreich, OMC patency)
Nasal polyp characterization (e.g. NPS & other variants)
Assessment of wound healing (e.g. Olfactory Fossa depth)
Mucosal modeling to evaluate disease burden and progression over time
Modeling of airway restrictions and central canal stenosis
Some of Our Experts
John Pallanch, MD, MS, FACS
Mayo Clinic
Dr. Pallanch is widely acknowledged as one of the very first to conceptualize and study the objective quantification of disease burden in patients with CRS using 3D volumetric staging. Dr. Pallanch has over 30 years of experience in clinical and surgical practice, research, and teaching. He is a pioneer in 3D image analysis for the study of the paranasal sinuses and nasal obstruction, for multiple applications including pre-op planning and extent of disease. He is a past board member of the American Rhinologic Society and ISIAN, served on the Editorial Board of the International Forum of Allergy and Rhinology, and currently serves as a reviewer for multiple journals. In addition to lecturing in 25+ countries, he has authored a dissection manual for rhinologic surgery, a DVD teaching 3D image analysis for surgical planning, and 2 theses on rhinologic physiology. He continues research on 3D image analysis.
Martin Citardi, MD, FACS
Dr. Citardi serves as Professor and Chair of the Department Otorhinolaryngology-Head and Neck Surgery at McGovern Medical School at The University of Texas Health Science Center at Houston. He also holds the position of Service Line Chief for the Memorial Hermann – Otorhinolaryngology-Head & Neck Surgery. Dr. Citardi is an internationally recognized Rhinologist, has over 100 publications and has authored book chapters. He was also a former director of the American Rhinologic Society. He has been a Houstonia Top Doctor since 2014, Castle Connolly Top Doctor since 2013 and a Texas Super Doctor since 2012.
Let MMI provide insights into your clinical study imaging.
Have questions? We’ll connect you immediately to one of our scientific managers and imaging experts. Your time is precious, and we want to make the most out of it.
