Orthopedics

The MMI Advantage

Experience and Expertise

MMI has over fifteen years of experience in providing core lab support for more than 150 orthopedic device and biopharmaceutical companies internationally, including 14 of the top 15 global market leaders.

Modality Expertise

X-ray

MRI

CT

Ultrasound

At MMI, we have evaluated well over 100 unique treatments for musculoskeletal disorders of the hip, knee, ankle, wrist, shoulder, elbow, peripheral joints, and long bones involving osteoarthritis, rheumatoid arthritis, trauma, and sports medicine. Broadly, our musculoskeletal treatment experience includes but is not limited to drugs, stem cells, biologics, viscosupplements, marrow stimulation, tissue grafting, ablation, bone fillers, fixation devices, bioresorbable scaffolds, biphasic implants, biomimetic devices, resurfacing, and partial and total arthroplasty.

We are experienced in virtually all major quantitative and semi-quantitative scoring systems to assess disease severity and response to therapy from medical imaging. When appropriate, we apply validated, computer-assisted methods to objectively document the effect of new treatments. We offer a variety of validated tools and techniques to facilitate these evaluations. Our proprietary and patented technology, QMA^®, offers unique quantitation and visualization capabilities that improve the reliability of common assessments, including change in joint space width and alignment; implant migration, subsidence, and rotation; progressive bone/implant interface remodeling; and fracture reduction, stabilization, and healing. Learn more here.

WHAT WE OFFER

Analysis Capabilities

Tissue structure, morphometry, and hydration (e.g. thickness, volume, lesion depth, T2 and T1ρ relaxation mapping)

Soft tissue repair & regeneration (cartilage, meniscus, tendon, ligament, muscle)

Joint space width and narrowing

Joint stability and alignment

Whole joint health semi-quantitative scoring systems

Implant stability, fixation, and alignment

Bone-implant and cement-implant interface remodeling

Structural bony anatomy (e.g. osteophytes, cysts, HO)

Fracture reduction, stabilization, and healing

Radiographic joint space width using the mid-coronal plane measurement method

MR relaxation mapping of knee cartilage

Preoperative rotator cuff tear length on sagittal MR

Femoral bone density analysis from CT

Successful fusion of the MTP at 24 months

3D surface of cartilage created from an MRI

Tibial cartilage thickness mapping

Acetabular cup inclination and obturator-tear drop distance measurements to assess coverage and pelvic positioning, respectively

Some of Our Experts

Timothy Mosher, MD

Kenneth L. Chair, Department of Radiology and Distinguished Professor of Radiology and Orthopaedic Surgery at Penn State University

Dr. Mosher is a clinical musculoskeletal radiologist with a research interest in osteoarthritis. He is a fellow of the International Society for Magnetic Resonance in Medicine (ISMRM) and has served on numerous NIH scientific review groups, the Scientific Advisory Board for the Canadian Arthritis Network, the Canadian Foundation for Innovation, and as an industry consultant in the areas of imaging applications to musculoskeletal projects. Dr. Mosher has published over 80 books and manuscripts with the majority in the area of musculoskeletal imaging, quantitative cartilage imaging, and MRI technical development.

William Morrison, MD FACR

Professor of Radiology and Director of Musculoskeletal Radiology at Thomas Jefferson University Hospital

Dr. Morrison is an internationally recognized authority in musculoskeletal imaging with over 30 years’ experience. He has co-authored or edited 13 textbooks including Problem Solving in Musculoskeletal Radiology and Imaging of the Musculoskeletal System, and published 100 book chapters and over 150 peer-reviewed articles. Dr. Morrison has served on the editorial board of the journals Radiology, Skeletal Radiology, and Seminars in Musculoskeletal Radiology. He has served on Expert Panels for the American College of Radiology (ACR), the American Board of Radiology (ABR), and the American Diabetes Association (ADA). He is also a past president of the Society of Skeletal Radiology (SSR).

Relevant Scientific Resources

Ortho Webinar

Knee Osteoarthritis Clinical Trial Design: An Imaging-Based Approach

MMI’s orthopedics expert discusses the imaging modalities and endpoints relevant for the design of knee OA clinical trials.

Measuring the effect of OA in the knee joint requires specialized expertise.

Ortho Trials

Best positioning for radiography of the knee in OA clinical trials

Drs. T.J. Mosher and G.E. Gold, two of MMI's thought leaders, recently were published in a review of the best practices for knee OA imaging in clinical trials.

Ortho Publication

Recent reviews explore best practices for hip osteoarthritis clinical trials

Facing an aging population and unprecedented scrutiny over treatment costs, clinical trials that seek to improve treatment of late-stage conditions and diseases such as osteoarthritis are set to make a significant impact.

Key Publications Involving MMI

Athwal GS, Krupp RJ, Carlson G, Bicknell RT. A multicenter, prospective 2-year analysis of the Sidus stem-free shoulder arthroplasty system. JSES Int. 2019;4(1):120-126.

Bugbee WD, Kolessar DJ, Davidson JS, Gibbon AJ, Lesko JP, Cosgrove KD. Single Use Instruments for Implanting a Contemporary Total Knee Arthroplasty System Are Accurate, Efficient, and Safe. J Arthroplasty. 2021;36(1):135-139.e2.

Chan EF, Cockman MD, Goel P, Newman PS, Hipp JA. Characterization of the mid-coronal plane method for measurement of radiographic change in knee joint space width across different levels of image parallax. Osteoarthritis Cartilage. 2021;29(9):1306-1313

Hipp JA, Chan EF. Threshold Limit Graphical Approach to Understanding Outcome Predictive Metrics: Data from the Osteoarthritis Initiative. Cureus. 2017;9(7):e1447

Lindgren K, Anderson MB, Peters CL, Pelt CE, Gililland JM. The Prevalence of Positive Findings on Metal Artifact Reduction Sequence Magnetic Resonance Imaging in Metal-on-Metal Total Hip Arthroplasty. J Arthroplasty. 2016;31(7):1519-1523.

Malone A, Kowalski MM, Helliwell J, Lynggaard Boll S, Rovsing H, Moriat K, Castillo Mondragón A, Li Y, Prener Miller C, Reinstrup Bihlet A, Dobek C, Peck V, Wilmink M, Simon LS, Conaghan PG. Efficacy and safety of a diffusion-based extended-release fluticasone propionate intra-articular injection (EP-104IAR) in knee osteoarthritis (SPRINGBOARD): a 24-week, multicentre, randomised, double-blind, vehicle-controlled, phase 2 trial. Lancet Rheumatol. 2024;6(12):e860-e870.

Verborgt O, Hachem AI, Eid K, Vuylsteke K, Ferrand M, Hardy P. Accuracy of patient-specific guided implantation of the glenoid component in reversed shoulder arthroplasty. Orthop Traumatol Surg Res. 2018;104(6):767-772.

Let MMI provide insights into your clinical study imaging.

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