Technology & Expertise

Complex studies of novel spine treatments and diagnostics require accurate and precise quantitative methods to objectively document the state of the spine prior to treatment and any response following treatment.  We offer a variety of validated tools and techniques to facilitate these evaluations.

Quantitative Motion Analysis (QMA®)

Our validated, proprietary, and patented Quantitative Motion Analysis (QMA®) software produces highly accurate and precise measurements of intervertebral motion from spine radiographs. Attributes of the software include:

  • At least 4 times more accurate than conventional measurement techniques
  • Validated for accuracy and reproducibility in at least ten published studies
  • Used in many trials of FDA-approved implants, including several “firsts”
  • Proven to increase observer reliability for common visual assessments through a proprietary visualization technique called Feature StabilizationTM
  • Cited in over 150 peer-reviewed publications and hundreds of abstracts
  • Widely regarded as the “gold standard” for quantitative image analysis
  • Used to compile authoritative databases and reference data on kinematics

Note: QMA® is designed for investigational use only and is not for use in clinical diagnosis or patient management.

Quantitative Computed Tomography (qCT)

We provide specialized expertise in quantitative methods for CT image processing, including:

  • Quantitative assessment of bone density using specialized phantoms
  • Volumetric analysis of spine fusion and the extent of new bone formation
  • Objective structural assessment of spinal fusion mass
  • Vertebral fracture risk prediction
  • Analysis of structural consequences of bone defects
  • Quantitative analysis of bone removal and decompression
  • Advanced image registration for visualization and quantification
  • Pre-clinical (micro-CT) analysis of vertebral porosity, morphology, and interdigitation of cement

Quantitative Magnetic Resonance Imaging  (qMRI)

We offer specialized techniques for quantitative analysis of MRI, including:

  • Quantitative analysis of disc signal intensity changes on a continuous scale
  • T1ρ relaxation mapping to assess composition and “disc health”
  • T2 relaxation mapping to assess changes in tissue hydration
  • Morphologic analysis of the annulus, nucleus, and other tissues
  • Analysis of injected material, including changes in position and volume
  • Quantitative analysis of central canal and neuroforaminal dimensions
  • Measurement of change in soft volume using 3D MRI sequences

Please browse our services or contact us to learn more.