Technology & Expertise

The ability to quantify features from medical images and accurately assess changes in these features in response to therapy has emerged as a standard end-point in clinical studies of orthopedic treatments. Where appropriate, we apply precise, quantitative methods to objectively document responses to treatment for osteoporosis, trauma, OA and RA. We offer a variety of validated tools and techniques to facilitate these evaluations.

Quantitative Motion Analysis (QMA®)

QMA® is a patented, image analysis technique that produces high-precision measurements from radiographic images. The technique is less prone to measurement error compared to conventional techniques and has been independently validated in multiple scientific studies. QMA® offers unique image analysis and visualization capabilities that improve the reliability of common assessments, including:

  • Change in joint space width and alignment
  • Implant migration, subsidence, and rotation
  • Progressive bone/implant interface radiolucency
  • Fracture reduction, stabilization, and healing

Note: QMA® is designed for investigational use only and not for use in clinical diagnosis or patient management.

Quantitative Computed Tomography (qCT)

We have extensive experience with a variety of quantitative CT processing techniques including:

  • Bone density analysis using specialized imaging phantoms
  • Analysis of bone volume and the extent of new bone formation
  • Objective structural assessment of fusion mass and degree of healing
  • Fracture risk prediction
  • Advanced visualization and quantification of response to therapy

Quantitative MRI (qMRI)

We have extensive experience with quantitative MRI methods to evaluate changes in the quality and quantity of cartilage and surrounding bone. The following evaluations are supported:

  • Cartilage and lesion depth, diameter, area, and volume
  • Cartilaginous and denuded subchondral bone area
  • T1ρ mapping and assessment of composition (proteoglycan and GAG)
  • T2 mapping and assessment of cartilage hydration
  • Advanced image registration to facilitate visualization and quantification of treatment effects

Please browse our services or contact us to learn more.